Neurobehavioral actions of cannabichromene and interactions with delta 9-tetrahydrocannabinol

Gen Pharmacol. 1983;14(2):247-52. doi: 10.1016/0306-3623(83)90004-6.

Abstract

1. Neither cannabichromene (CBC) nor delta 9-tetrahydrocannabinol (THC) protected mice from electroshock-induced seizures, although THC inhibited postictal mortality. Minor effects were produced on seizure latency and duration. 2. CBC had a weak analgetic action in mice; THC had a moderate and lengthy effect, which was potentiated at 2 hr by concurrent CBC. 3. Both CBC (10-75 mg/kg, i.p.) and THC (20 mg/kg) reduced motility of mice, the THC equalling the highest dose of CBC. 4. Performance of a conditioned avoidance response was strongly impaired by THC, but not by CBC, nor did CBC combined with THC have influence on the effects of THC.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analgesics / pharmacology
  • Animals
  • Anticonvulsants / pharmacology
  • Avoidance Learning / drug effects
  • Behavior, Animal / drug effects*
  • Brain / drug effects*
  • Cannabinoids / pharmacology*
  • Central Nervous System Depressants / pharmacology*
  • Dronabinol / pharmacology*
  • Drug Interactions
  • Electroshock
  • Male
  • Mice
  • Mice, Inbred ICR
  • Motor Activity / drug effects

Substances

  • Analgesics
  • Anticonvulsants
  • Cannabinoids
  • Central Nervous System Depressants
  • Dronabinol
  • cannabichromene