Myelination in rabbit optic nerves is accelerated by artificial eye opening

Neurosci Lett. 1980 Mar;16(3):235-8. doi: 10.1016/0304-3940(80)90003-8.


Artificial opening of the eyes of young rabbits on the 5th postnatal day led to accelerated myelination: the myelin-specific basic and proteolipid proteins nearly doubled between the 7th and the 10th postnatal days when compared to controls; 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP) activity also increased by about 60%. Conversely, lowered AChE activities presumably reflected elevated myelin/axolemma ratios. Myelination in treated animals normalized during later ontogenetic stages (greater than 20th postnatal day).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 2',3'-Cyclic-Nucleotide Phosphodiesterases / metabolism
  • Animals
  • Animals, Newborn / growth & development*
  • Cell Count
  • Light
  • Myelin Proteins / analysis
  • Myelin Sheath / physiology*
  • Nerve Fibers, Myelinated
  • Optic Nerve / cytology
  • Optic Nerve / growth & development*
  • Optic Nerve / metabolism
  • Rats


  • Myelin Proteins
  • 2',3'-Cyclic-Nucleotide Phosphodiesterases