Abstract
Ketoconazole is an imidazole derivative recently developed as an antifungal agent. There have been only a few established cases of hepatotoxicity in the literature. This report describes a case of presumed ketoconazole hepatotoxicity characterized by the development of severe hepatitis with marked centrilobular necrosis. The lack of hypersensitivity reactions in clinical findings and centrilobular location of necrosis suggested a host idiosyncrasy with metabolic abnormality as the effect of ketoconazole in the present case.
MeSH terms
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Adult
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Alanine Transaminase / blood
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Antifungal Agents / adverse effects*
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Aspartate Aminotransferases / blood
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Biopsy
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Chemical and Drug Induced Liver Injury / enzymology
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Chemical and Drug Induced Liver Injury / etiology*
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Chemical and Drug Induced Liver Injury / pathology
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Dermatomycoses / drug therapy
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Female
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Humans
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Imidazoles / adverse effects*
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Ketoconazole
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Liver / drug effects
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Liver / pathology
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Piperazines / adverse effects*
Substances
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Antifungal Agents
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Imidazoles
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Piperazines
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Aspartate Aminotransferases
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Alanine Transaminase
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Ketoconazole