Comparison of miconazole- and ketoconazole-induced release of K+ from Candida species

J Antimicrob Chemother. 1983 Apr;11(4):381-3. doi: 10.1093/jac/11.4.381.

Abstract

Relatively high concentrations of miconazole caused immediate and rapid release of K+ from strains of Candida albicans and Can. parapsilosis. Ketoconazole did not. These results support the recent hypothesis that ketonocazole, unlike related antifungal imidazole-containing drugs, cannot exert a direct membrane damaging effect.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Antifungal Agents / pharmacology*
  • Candida / drug effects*
  • Candida / metabolism
  • Imidazoles / pharmacology*
  • Ketoconazole
  • Miconazole / pharmacology*
  • Piperazines / pharmacology*
  • Potassium / metabolism*

Substances

  • Antifungal Agents
  • Imidazoles
  • Piperazines
  • Miconazole
  • Ketoconazole
  • Potassium