Growth of chromosome ends in multiplying trypanosomes

Nature. 1983 Jun 16-22;303(5918):592-7. doi: 10.1038/303592a0.

Abstract

Some of the genes for the variant surface glycoproteins of trypanosomes are located close to a discontinuity in the DNA, presumably a chromosome end. We show here that DNA fragments containing these telomeres increase in length in multiplying trypanosomes at a rate of about 10 base pairs per division. We argue that chromosome growth may not be restricted to trypanosomes and could explain the heterogeneity of telomeric DNA fragments observed in some other organisms.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • Chromosomes / physiology*
  • DNA Replication*
  • DNA Restriction Enzymes
  • Genes
  • Genetic Variation
  • Glycoproteins / genetics
  • Nucleic Acid Hybridization
  • Trypanosoma / genetics
  • Trypanosoma / physiology*

Substances

  • Glycoproteins
  • DNA Restriction Enzymes