Heterogeneity of leukotriene receptors in guinea-pig trachea

Prostaglandins. 1983 Feb;25(2):171-8. doi: 10.1016/0090-6980(83)90102-8.

Abstract

The selective leukotriene (LT) antagonist FPL 55712 antagonized the contractile activity of synthetic LTD4 and E4 on guinea-pig trachea. Schild analysis of the antagonism provided evidence for two distinct receptors for LTD4: one with significantly higher affinity for FPL 55712 than the other. LTE4 appears to interact preferentially with the high affinity receptor.

MeSH terms

  • Animals
  • Chromones / pharmacology
  • Guinea Pigs
  • Kinetics
  • Leukotriene E4
  • Male
  • Muscle Contraction / drug effects
  • Receptors, Cell Surface / metabolism*
  • Receptors, Leukotriene
  • SRS-A / analogs & derivatives*
  • SRS-A / metabolism*
  • SRS-A / pharmacology
  • Structure-Activity Relationship
  • Trachea / physiology*

Substances

  • Chromones
  • Receptors, Cell Surface
  • Receptors, Leukotriene
  • SRS-A
  • Leukotriene E4
  • FPL 55712