Regulation of Human Placental Deoxyguanosine Kinase by Nucleotides

FEBS Lett. 1983 Jun 27;157(1):51-3. doi: 10.1016/0014-5793(83)81114-4.

Abstract

The activity of deoxyguanosine kinase purified from human placenta was regulated by various nucleotides. dTTP, an activator, only increased the Vmax value of the enzyme. The feedback inhibition by dGTP, dGDP and dGMP were competitive with respect to deoxyguanosine. Both the activation by dTTP and the inhibition by dGTP were reversible.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Deoxyguanine Nucleotides / pharmacology
  • Enzyme Activation / drug effects
  • Female
  • Humans
  • Nucleotides / pharmacology*
  • Phosphotransferases (Alcohol Group Acceptor)*
  • Phosphotransferases / antagonists & inhibitors
  • Phosphotransferases / metabolism*
  • Placenta / enzymology*
  • Thymine Nucleotides / pharmacology

Substances

  • Deoxyguanine Nucleotides
  • Nucleotides
  • Thymine Nucleotides
  • deoxyguanosine triphosphate
  • Phosphotransferases
  • Phosphotransferases (Alcohol Group Acceptor)
  • deoxyguanosine kinase
  • thymidine 5'-triphosphate