Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 1983 Aug;24(8):767-71.
doi: 10.1136/gut.24.8.767.

Wilson's Disease and Hepatocellular Carcinoma: Possible Protective Role of Copper

Free PMC article
Case Reports

Wilson's Disease and Hepatocellular Carcinoma: Possible Protective Role of Copper

M L Wilkinson et al. Gut. .
Free PMC article

Abstract

A male patient with Wilson's disease developed a hepatocellular carcinoma after treatment for nine years with D-penicillamine. Examination at necropsy showed that excess liver copper had been effectively removed. As copper has been shown to protect against chemically induced hepatocellular carcinoma in rats, this may be the reason for the extreme rarity of hepatocellular carcinoma in patients with Wilson's disease and possibly in other liver diseases with hepatic copper overload.

Similar articles

See all similar articles

Cited by 12 articles

See all "Cited by" articles

References

    1. Histopathology. 1980 Nov;4(6):637-43 - PubMed
    1. Gut. 1978 Nov;19(11):1022-6 - PubMed
    1. Gut. 1979 Mar;20(3):255-8 - PubMed
    1. Br J Cancer. 1958 Dec;12(4):594-608 - PubMed
    1. Lancet. 1959 Feb 7;1(7067):275-6 - PubMed

Publication types

Feedback