Structure and organization of the human Ki-ras proto-oncogene and a related processed pseudogene

Nature. 1983 Aug 11-17;304(5926):501-6. doi: 10.1038/304501a0.


Analysis of the organization and nucleotide sequence of two human loci related to the transforming gene of Kirsten murine sarcoma virus establishes one as a functional gene and the other as a processed pseudogene. The two final coding exons of the functional gene seem to have arisen by duplication. Differentially spliced mRNAs incorporating one or other of the duplicated exons probably served as the intermediates by which the viral transforming gene and the pseudogene were generated. This suggests that the functional gene may specify either of two related polypeptides depending on the pattern of RNA splicing.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Biological Evolution
  • Cell Transformation, Viral*
  • Cloning, Molecular
  • Gene Expression Regulation
  • Humans
  • Kirsten murine sarcoma virus / genetics*
  • Oncogenes*
  • RNA Processing, Post-Transcriptional
  • RNA Splicing
  • Sarcoma Viruses, Murine / genetics*
  • Viral Proteins / genetics


  • Viral Proteins

Associated data

  • GENBANK/K00652
  • GENBANK/K00653
  • GENBANK/K01912
  • GENBANK/L00044
  • GENBANK/L00045
  • GENBANK/L00046
  • GENBANK/L00047
  • GENBANK/L00048
  • GENBANK/L00049