Ca2+ in the control of active intestinal Na and Cl transport: involvement in neurohumoral action

Am J Physiol. 1983 Aug;245(2):G165-77. doi: 10.1152/ajpgi.1983.245.2.G165.


Intracellular Ca2+ is a regulator of active intestinal Na and Cl transport. Most studies have been done with rabbit ileum. Increasing intracellular Ca2+ decreases active Na and Cl absorption and/or stimulates active Cl secretion; lowering intracellular Ca2+ stimulates Na and Cl absorption. Based on studies with microvillus membrane vesicles from rabbit ileum, a direct effect of Ca2+ and calmodulin on linked Na and Cl uptake is established. Intracellular Ca2+ and cAMP affect the same transport processes and act in a nonadditive manner. Intracellular Ca2+ does not act by changing intestinal cAMP or cGMP contents, and increasing cAMP mobilizes intracellular Ca2+. Whether this Ca2+ is involved in regulation of ion transport is not known. The aspects of Ca2+ handling identified as involved in regulation of active intestinal Na and Cl transport include entry of Ca2+ across the basolateral membrane, mobilization of Ca2+ from intracellular stores, and involvement of the Ca2+-binding protein calmodulin. Several neurohumoral substances alter intestinal transport by Ca2+-dependent mechanisms and appear to act primarily by increasing (serotonin, carbachol, substance P, and neurotensin) or decreasing (dopamine) Ca2+ entry across the basolateral membrane of intestinal epithelial cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Calcium / metabolism*
  • Calcium / pharmacology
  • Calcium-Transporting ATPases / metabolism
  • Calmodulin / metabolism
  • Chlorides / metabolism*
  • Colon / metabolism
  • Cyclic AMP / metabolism
  • Cytosol / metabolism
  • Ileum / drug effects
  • Ileum / metabolism
  • Intestinal Absorption* / drug effects
  • Ion Channels / metabolism
  • Rabbits
  • Sodium / metabolism*


  • Calmodulin
  • Chlorides
  • Ion Channels
  • Sodium
  • Cyclic AMP
  • Calcium-Transporting ATPases
  • Calcium