Abstract
Simian virus 40 chromosomes carry out replicative DNA synthesis in vitro which is sensitive to aphidicolin and to N-ethylmaleimide, resistant to 2',3'-dideoxythymidine-5'-triphosphate, and proportional to the amount of chromosome-associated alpha-like polymerase. Thus, an alpha-like DNA polymerase (alpha polymerase or delta polymerase) is responsible for in vitro DNA synthesis.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Aphidicolin
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DNA Polymerase II / metabolism*
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DNA Replication
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DNA, Viral / biosynthesis*
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DNA-Directed DNA Polymerase / metabolism*
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Dideoxynucleotides
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Diterpenes / pharmacology
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Ethylmaleimide / pharmacology
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Simian virus 40 / enzymology*
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Thymine Nucleotides / pharmacology
Substances
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DNA, Viral
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Dideoxynucleotides
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Diterpenes
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Thymine Nucleotides
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Aphidicolin
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DNA Polymerase II
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DNA-Directed DNA Polymerase
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2',3'-dideoxythymidine triphosphate
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Ethylmaleimide