Abstract
We have isolated and sequenced a cDNA clone coding for human haptoglobin. Our sequence shows that haptoglobin is very likely synthesized as a single polypeptide chain which is then cleaved at an Arg residue to generate its two characteristic alpha and beta subunit. Southern blot analysis suggests that there are at least two copies of the haptoglobin gene per haploid genome.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Base Sequence
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Cloning, Molecular*
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DNA* / isolation & purification
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Escherichia coli / genetics
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Genetic Vectors
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Haptoglobins / genetics*
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Humans
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Macromolecular Substances
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Nucleic Acid Hybridization
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Plasmids
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RNA, Messenger / genetics*
Substances
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Haptoglobins
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Macromolecular Substances
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RNA, Messenger
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DNA
Associated data
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GENBANK/M12387
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GENBANK/X00442