Amdinocillin therapy of experimental animal infections

Am J Med. 1983 Aug 29;75(2A):48-53. doi: 10.1016/0002-9343(83)90093-1.

Abstract

Amdinocillin has been shown to have broad coverage in vitro against many strains of Enterobacteriaceae. Synergy has been demonstrated in vitro with several other beta-lactam antibiotics. The rabbit model of meningitis was used to study the in vivo effectiveness of amdinocillin when combined with other beta-lactams for serious infections. Organisms that showed an enhanced in vitro bactericidal effect from the combination of amdinocillin and another beta-lactam showed more rapid elimination of the organisms in vivo.

Publication types

  • Review

MeSH terms

  • Amdinocillin / therapeutic use*
  • Animals
  • Anti-Bacterial Agents / therapeutic use*
  • Bacterial Infections / drug therapy*
  • Disease Models, Animal
  • Drug Synergism
  • Drug Therapy, Combination
  • Escherichia coli Infections / drug therapy
  • Klebsiella Infections / drug therapy
  • Klebsiella pneumoniae
  • Meningitis / drug therapy
  • Penicillanic Acid / therapeutic use*

Substances

  • Anti-Bacterial Agents
  • Penicillanic Acid
  • Amdinocillin