Phosphorylation of isocitrate dehydrogenase as a demonstration of enhanced sensitivity in covalent regulation

Nature. 1983 Sep;305(5932):286-90. doi: 10.1038/305286a0.

Abstract

The sensitivity to regulation of proteins undergoing covalent modification can be greatly increased when the substrates saturate the converter enzymes. This phenomenon, termed zero-order ultrasensitivity, has been found to occur in the reversible phosphorylation of isocitrate dehydrogenase. The possibility that this enhanced sensitivity is a common feature of covalent regulatory systems is discussed.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Allosteric Regulation
  • Enzyme Activation
  • Isocitrate Dehydrogenase / metabolism*
  • Kinetics
  • Phosphoprotein Phosphatases / metabolism
  • Phosphoproteins / metabolism
  • Phosphorylation
  • Protein Kinases / metabolism

Substances

  • Phosphoproteins
  • Isocitrate Dehydrogenase
  • Protein Kinases
  • Phosphoprotein Phosphatases