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, 305 (5932), 286-90

Phosphorylation of Isocitrate Dehydrogenase as a Demonstration of Enhanced Sensitivity in Covalent Regulation

Phosphorylation of Isocitrate Dehydrogenase as a Demonstration of Enhanced Sensitivity in Covalent Regulation

D C LaPorte et al. Nature.

Abstract

The sensitivity to regulation of proteins undergoing covalent modification can be greatly increased when the substrates saturate the converter enzymes. This phenomenon, termed zero-order ultrasensitivity, has been found to occur in the reversible phosphorylation of isocitrate dehydrogenase. The possibility that this enhanced sensitivity is a common feature of covalent regulatory systems is discussed.

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