Associated endocrine, physiological and behavioral changes in rhesus monkeys after intravenous corticotropin-releasing factor administration

Peptides. Mar-Apr 1983;4(2):211-5. doi: 10.1016/0196-9781(83)90116-x.

Abstract

The intravenous (IV) administration of synthetic ovine corticotropin-releasing factor (CRF) (10 and 125 micrograms/kg) to chair restrained rhesus monkeys stimulated the pituitary-adrenal axis. At these doses, increases in plasma concentrations of adrenocorticotropic hormone (ACTH) and cortisol were associated with blood pressure decreases and behavioral effects. These data demonstrate that synthetic ovine CRF (10 and 125 micrograms/kg) administered IV to the rhesus monkey results in associated endocrine, physiological, and behavioral changes.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adrenocorticotropic Hormone / blood*
  • Animals
  • Behavior, Animal / drug effects*
  • Blood Pressure / drug effects*
  • Corticotropin-Releasing Hormone / administration & dosage
  • Corticotropin-Releasing Hormone / pharmacology*
  • Exploratory Behavior / drug effects
  • Heart Rate / drug effects*
  • Hydrocortisone / blood*
  • Injections, Intravenous
  • Kinetics
  • Macaca mulatta
  • Motor Activity / drug effects
  • Pituitary-Adrenal System / drug effects
  • Pituitary-Adrenal System / physiology*
  • Restraint, Physical

Substances

  • Adrenocorticotropic Hormone
  • Corticotropin-Releasing Hormone
  • Hydrocortisone