Hyperpolarization following long-lasting tetanic activation of hippocampal pyramidal cells

Brain Res. 1983 Sep 19;275(1):159-63. doi: 10.1016/0006-8993(83)90429-8.


Long-lasting spike activation of CA3 hippocampal pyramidal neurons is shown to cause the development of a large and long-lasting (greater than 50 s) membrane hyperpolarization (PTH). Under normal conditions this PTH is mainly given by a relatively potential-independent process, presumably an electrogenic sodium pump. Following reduction in pump activity (cooling, ouabain), the PTH remains but is mainly produced by a conductance process, presumably a K conductance increase resulting from a sodium-induced calcium release from intracellular stores.

MeSH terms

  • Action Potentials*
  • Animals
  • Cell Membrane Permeability
  • Guinea Pigs
  • Hippocampus / physiology*
  • In Vitro Techniques
  • Ion Channels / physiology
  • Ouabain / pharmacology
  • Potassium / metabolism
  • Synapses / physiology
  • Synaptic Transmission*
  • Tetrodotoxin / pharmacology


  • Ion Channels
  • Tetrodotoxin
  • Ouabain
  • Potassium