Ranitidine kinetics in chronic renal impairment

Clin Pharmacol Ther. 1983 Nov;34(5):667-72. doi: 10.1038/clpt.1983.230.


The effects of moderate to severe renal impairment on kinetics of the H2-blocker ranitidine were investigated in 16 patients divided into two groups. Mean inulin clearance (ClIn) was 35 +/- 18.3 ml/min/1.73 m2 in group I and 7.4 +/- 3.5 ml/min/1.73 m2 in group II. Each patient received a single 150-mg oral dose of ranitidine. Values determined were maximum plasma concentration (MC) and time of occurrence, AUC, elimination t 1/2 (t 1/2 beta), total amount of unchanged ranitidine recovered in urine, and ranitidine renal clearance (ClR). MC values were higher and longer delayed than values reported in subjects with normal renal function. The t 1/2 beta was longer in group I and group II and correlated with the degree of renal impairment. The amount of ranitidine excreted within the first 24 hr decreased (18% of the dose in group I and 6% of the dose in group II), and ClR correlated strongly with ClIn, indicating that the observed changes in ranitidine kinetics are mainly related to changes in its renal excretion.

MeSH terms

  • Adult
  • Aged
  • Female
  • Humans
  • Kidney Diseases / metabolism*
  • Kidney Function Tests
  • Kinetics
  • Male
  • Middle Aged
  • Ranitidine / metabolism*


  • Ranitidine