Sequence of the lacZ gene of Escherichia coli

EMBO J. 1983;2(4):593-7.


The nucleotide sequence of the lacZ gene coding for beta-galactosidase (EC in Escherichia coli has been determined. Beta-Galactosidase is predicted to consist of 1023 residues, resulting in a protein with a mol. wt. of 116 353 per subunit. The protein sequence originally determined by Fowler and Zabin was shown to be essentially correct and in an Appendix these authors comment on the discrepancies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacterial Proteins / genetics*
  • Base Sequence
  • Escherichia coli / genetics*
  • Galactosidases / genetics*
  • Genes, Bacterial*
  • Genetic Vectors
  • Lac Operon*
  • Plasmids
  • beta-Galactosidase / genetics*


  • Bacterial Proteins
  • Galactosidases
  • beta-Galactosidase

Associated data

  • GENBANK/J01636
  • GENBANK/J01637
  • GENBANK/K01483
  • GENBANK/K01793