Abstract
The validity and clinical usefulness of receptor binding studies of psychotropic drugs, particularly the antidepressants, is examined. Data on the affinities of antidepressants for several different neurotransmitter receptors in human brain are presented along with other pharmacologic data on these drugs.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Antidepressive Agents / blood
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Antidepressive Agents / pharmacology*
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Antidepressive Agents / therapeutic use
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Antidepressive Agents, Tricyclic / blood
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Antidepressive Agents, Tricyclic / pharmacology
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Antidepressive Agents, Tricyclic / therapeutic use
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Humans
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Mental Disorders / drug therapy
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Radioligand Assay
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Receptors, Dopamine / drug effects
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Receptors, Drug / analysis
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Receptors, Drug / drug effects*
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Receptors, Histamine / drug effects
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Receptors, Muscarinic / drug effects
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Receptors, Neurotransmitter / drug effects
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Receptors, Serotonin / drug effects
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Structure-Activity Relationship
Substances
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Antidepressive Agents
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Antidepressive Agents, Tricyclic
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Receptors, Dopamine
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Receptors, Drug
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Receptors, Histamine
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Receptors, Muscarinic
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Receptors, Neurotransmitter
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Receptors, Serotonin