Immunocytochemical localization of ACTH perikarya in nucleus tractus solitarius: evidence for a second opiocortin neuronal system

Neurosci Lett. 1983 Aug 8;38(3):221-5. doi: 10.1016/0304-3940(83)90372-5.


Immunocytochemical localization of ACTH-opiocortin perikarya was demonstrated in the medulla of colchicine-treated rat. Neuronal cell bodies and fibers containing ACTH-immunoreactivity were abundant in the caudal region of the nucleus tractus solitarius, specifically within pars commisuralis. Location of these opiocortin neurons within the nucleus tractus solitarius provides additional evidence for a role of these peptides in cardiovascular functions.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adrenocorticotropic Hormone / analysis*
  • Animals
  • Dogs
  • Endorphins / physiology*
  • Hemodynamics
  • Histocytochemistry
  • Immunochemistry
  • Immunoenzyme Techniques
  • Medulla Oblongata / analysis
  • Medulla Oblongata / cytology*
  • Neurons / analysis*
  • Pituitary Hormones, Anterior / physiology*
  • Rats
  • Rats, Inbred Strains
  • Spinal Cord / analysis
  • Spinal Cord / cytology*


  • Endorphins
  • Pituitary Hormones, Anterior
  • Adrenocorticotropic Hormone