Centrally administered N-terminal fragments of ACTH (1-10, 4-10, 4-9) display convulsant properties in rabbits

Peptides. May-Jun 1983;4(3):315-8. doi: 10.1016/0196-9781(83)90140-7.

Abstract

Electroencephalographic and behavioral effects of the following ACTH fragments: 1-4, 4-9, 4-11, 1-10, 4-10, 1-13, 1-17 and 1-24 were studied in rabbits. Sequences 4-9, 1-10 and 4-10 displayed some epileptic properties, i.e., they induced epileptic seizures (only electrographic or also behavioral) or increased hippocampal spiking. The 4-9 sequence seemed to be the common sequence responsible for these proconvulsant effects. The possible involvement of the enkephalinergic system is discussed.

Publication types

  • Comparative Study

MeSH terms

  • Adrenocorticotropic Hormone / pharmacology*
  • Animals
  • Convulsants*
  • Hippocampus / drug effects
  • Injections, Intraventricular
  • Peptide Fragments / pharmacology*
  • Rabbits
  • Seizures / chemically induced

Substances

  • Convulsants
  • Peptide Fragments
  • ACTH (1-10)
  • ACTH (4-9)
  • Adrenocorticotropic Hormone
  • ACTH (4-10)