Detection of human papillomavirus DNA sequences in conjunctival papilloma

Am J Ophthalmol. 1983 Nov;96(5):670-4. doi: 10.1016/s0002-9394(14)73426-9.


Two histologically proven conjunctival papillomas (one from a 33-month-old boy and the other from a 28-year-old woman) were examined for the presence of papillomavirus by DNA molecular hybridization. The first case, a recurrent tumor known to be positive for papillomavirus structural antigen, demonstrated human papillomavirus DNA sequences that cross-hybridized to a human papillomavirus type 11 DNA probe. The second case, an initial tumor, which was negative for papillomavirus structural antigen, demonstrated no viral DNA sequences by hybridization.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Antigens, Viral / analysis
  • Child, Preschool
  • Conjunctival Neoplasms / microbiology*
  • DNA, Viral / analysis*
  • Female
  • Humans
  • Male
  • Nucleic Acid Hybridization
  • Papilloma / microbiology*
  • Papillomaviridae / analysis*


  • Antigens, Viral
  • DNA, Viral