Localization of the c-ab1 oncogene adjacent to a translocation break point in chronic myelocytic leukaemia

Nature. 1983 Nov 17-23;306(5940):239-42. doi: 10.1038/306239a0.

Abstract

The human c-ab1 oncogene maps within the region (q34-qter) of chromosome 9 which is translocated to chromosome 22, the Philadelphia (Ph') chromosome, in chronic myelocytic leukaemia (CML). The position of the Ph' chromosomal break point is shown to be variable and, in one CML patient, has been localized immediately 5' of, or within, the c-ab1 oncogene. A DNA restriction fragment corresponding to this site has been molecularly cloned and shown to represent a chimaeric fragment of DNA from chromosomes 9 and 22.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Abelson murine leukemia virus / genetics*
  • Chromosome Mapping
  • Chromosomes, Human, 21-22 and Y*
  • Chromosomes, Human, 6-12 and X*
  • Cloning, Molecular
  • DNA Restriction Enzymes
  • Gene Amplification
  • Humans
  • Leukemia Virus, Murine / genetics*
  • Leukemia, Myeloid / genetics*
  • Oncogenes*
  • Translocation, Genetic

Substances

  • DNA Restriction Enzymes