Abstract
A new polymorphic BgI II restriction endonuclease site in the alpha-globin gene complex has been found in Cypriot, Sardinian, and Greek populations. In all cases, this polymorphism is linked to a particular hypervariable region between the zeta 2 and zeta 1 genes. This suggests that these hypervariable regions are stable and will be useful for genetic analysis.
MeSH terms
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Chromosome Mapping*
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Chromosomes, Human, 16-18*
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Cyprus
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DNA / analysis
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DNA / genetics*
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DNA Restriction Enzymes
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Deoxyribonucleases, Type II Site-Specific*
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Genes*
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Globins / genetics*
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Greece
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Homozygote
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Humans
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Italy
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Polymorphism, Genetic*
Substances
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Globins
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DNA
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DNA Restriction Enzymes
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Deoxyribonucleases, Type II Site-Specific
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GCCNNNNNGGC-specific type II deoxyribonucleases