Association of two DNA polymorphisms in the alpha-globin gene cluster: implications for genetic analysis

Am J Hum Genet. 1983 Nov;35(6):1086-9.

Abstract

A new polymorphic BgI II restriction endonuclease site in the alpha-globin gene complex has been found in Cypriot, Sardinian, and Greek populations. In all cases, this polymorphism is linked to a particular hypervariable region between the zeta 2 and zeta 1 genes. This suggests that these hypervariable regions are stable and will be useful for genetic analysis.

MeSH terms

  • Chromosome Mapping*
  • Chromosomes, Human, 16-18*
  • Cyprus
  • DNA / analysis
  • DNA / genetics*
  • DNA Restriction Enzymes
  • Deoxyribonucleases, Type II Site-Specific*
  • Genes*
  • Globins / genetics*
  • Greece
  • Homozygote
  • Humans
  • Italy
  • Polymorphism, Genetic*

Substances

  • Globins
  • DNA
  • DNA Restriction Enzymes
  • Deoxyribonucleases, Type II Site-Specific
  • GCCNNNNNGGC-specific type II deoxyribonucleases