Viral and cellular fos proteins: a comparative analysis

Cell. 1984 Feb;36(2):259-68. doi: 10.1016/0092-8674(84)90219-8.


The FBJ murine osteosarcoma virus (FBJ-MuSV) induces osteosarcomas in mice and transforms fibroblasts in vitro. It contains an oncogene termed v-fos derived from a normal cellular gene by recombination with an associated helper virus. The product of the v-fos gene is a 55,000 dalton protein, p55v-fos. This protein was found in the nuclei of cells containing amplified levels of the v-fos gene, and also in the nuclei of virus-transformed cells. The c-fos protein was localized in the nuclei of normal mouse amnion cells and in the nuclei of cells transformed by a recombinant plasmid that expresses the c-fos gene product. However, p55c-fos undergoes more extensive post-translational modification in the nucleus than p55v-fos. Immunofluorescence data indicate that the level of p55c-fos in normal mouse amnion cells is similar to that found in fibroblasts transformed by the v-fos or c-fos proteins.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amnion
  • Animals
  • Cell Line
  • Cricetinae
  • Cricetulus
  • DNA Restriction Enzymes
  • DNA, Recombinant
  • Female
  • Gene Amplification
  • Genes*
  • Genes, Viral*
  • Mice
  • Oncogenes*
  • Ovary
  • Plasmids
  • Pregnancy
  • Tetrahydrofolate Dehydrogenase / genetics
  • Transfection
  • Viral Proteins / genetics*
  • Viral Proteins / isolation & purification


  • DNA, Recombinant
  • Viral Proteins
  • Tetrahydrofolate Dehydrogenase
  • DNA Restriction Enzymes