Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences

Nature. 1984 Feb 9-15;307(5951):521-7. doi: 10.1038/307521a0.

Abstract

Each of six peptides derived from the human epidermal growth factor (EGF) receptor very closely matches a part of the deduced sequence of the v-erb-B transforming protein of avian erythroblastosis virus (AEV). In all, the peptides contain 83 amino acid residues, 74 of which are shared with v-erb-B. The AEV progenitor may have acquired the cellular gene sequences of a truncated EGF receptor (or closely related protein) lacking the external EGF-binding domain but retaining the transmembrane domain and a domain involved in stimulating cell proliferation. Transformation of cells by AEV may result, in part, from the inappropriate acquisition of a truncated EGF receptor from the c-erb-B gene.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Cell Cycle
  • Cell Transformation, Viral*
  • Epidermal Growth Factor / physiology
  • ErbB Receptors
  • Humans
  • Oncogenes*
  • Receptors, Cell Surface* / isolation & purification

Substances

  • Receptors, Cell Surface
  • Epidermal Growth Factor
  • ErbB Receptors