Virus-associated hemophagocytic syndrome due to Epstein-Barr virus

Hum Pathol. 1984 Mar;15(3):290-3. doi: 10.1016/s0046-8177(84)80194-x.


The clinical and autopsy findings in a case of virus-associated hemophagocytic syndrome in a previously healthy 17-year-old girl are presented. Serum titers to Epstein-Barr viral antigens were unusually elevated. In addition to widespread proliferation of hemophagocytic histiocytes and lymphoid depletion, there were areas of non-suppurative necrosis in lymph nodes and spleen, which have not been previously reported.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Female
  • Herpesviridae Infections*
  • Herpesvirus 4, Human
  • Humans
  • Lymphatic Diseases / etiology*
  • Lymphatic Diseases / pathology
  • Phagocytosis