Variation in the structure of varicella-zoster virus DNA

Intervirology. 1984;21(1):25-37. doi: 10.1159/000149500.


By analyzing the fine structure of varicella-zoster virus (VZV) DNA, a naturally occurring heterogeneity was found on the right end of VZV DNA, but no evidence of a true terminal repetition was uncovered. We were unable to confirm the report of Straus and co-workers (1981) that there is a relatively high frequency of circular VZV DNA in low-passage virus. On long-term cell passage, extensive heterogeneity appeared concomitant with the accumulation of apparently defective VZV DNA.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Chromosome Mapping
  • DNA Restriction Enzymes
  • DNA, Circular / genetics
  • DNA, Viral / genetics*
  • Herpesvirus 3, Human / genetics*
  • Polymorphism, Genetic
  • Repetitive Sequences, Nucleic Acid


  • DNA, Circular
  • DNA, Viral
  • DNA Restriction Enzymes