Induction of altered chromatin structures by simian virus 40 enhancer and promoter elements

Nature. 1984 Feb 23-29;307(5953):708-14. doi: 10.1038/307708a0.


Two simian virus 40 transcriptional promoter elements, the 72-base pair (bp) repeat and the 21-bp repeat region, induce chromatin structures of increased DNase I sensitivity when transposed elsewhere in the viral genome. The induction of a sufficiently long stretch of DNase I-sensitive chromatin leads to the appearance of a visible nucleosome-free region.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromatin / ultrastructure*
  • DNA Replication
  • Deoxyribonucleases
  • Gene Expression Regulation*
  • Genes, Regulator
  • Nucleosomes / ultrastructure
  • Operon*
  • Repetitive Sequences, Nucleic Acid
  • Simian virus 40 / genetics*


  • Chromatin
  • Nucleosomes
  • Deoxyribonucleases