The receptor for transepithelial transport of IgA and IgM contains multiple immunoglobulin-like domains

Nature. 1984 Mar 1-7;308(5954):37-43. doi: 10.1038/308037a0.

Abstract

We have cloned and sequenced cDNA for the receptor that mediates the endocytosis and transcellular transport of IgA and IgM across many glandular epithelia into external secretions. This receptor contains five extracellular domains which are strikingly homologous to each other and to immunoglobulin variable regions.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cloning, Molecular*
  • DNA / analysis*
  • DNA Restriction Enzymes
  • Endocytosis
  • Female
  • Immunoglobulin A / metabolism*
  • Immunoglobulin M / metabolism*
  • Liver / immunology
  • Mammary Glands, Animal / immunology
  • Pregnancy
  • RNA, Messenger / genetics
  • Rabbits
  • Receptors, Immunologic / genetics*
  • Receptors, Immunologic / metabolism
  • Structure-Activity Relationship

Substances

  • Immunoglobulin A
  • Immunoglobulin M
  • RNA, Messenger
  • Receptors, Immunologic
  • DNA
  • DNA Restriction Enzymes

Associated data

  • GENBANK/K01291