Two types of mutants affecting voltage-sensitive sodium channels in Drosophila melanogaster

Nature. 1984 Mar;308(5955):189-91. doi: 10.1038/308189a0.


Voltage-sensitive sodium channels have a key role in the genesis of propagated action potentials. Mutations that affect these channels might be used like specific pharmacological agents in studies of channel structure and regulation. We have found that mutations which cause a reversible, temperature-induced paralysis in the fruit fly Drosophila melanogaster often affect the voltage-sensitive sodium channel. Using 3H-saxitoxin binding to membrane preparations, we have now identified two types of presumptive sodium channel mutants. One mutation, seizurets-2 (seits-2), appears to alter saxitoxin-binding sites structurally. The second, no-action-potential (napts) (refs 5, 6), reduces the number of saxitoxin-binding sites, but appears not to alter the receptor structure.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cell Membrane / metabolism
  • Drosophila melanogaster / genetics
  • Drosophila melanogaster / metabolism
  • Electric Conductivity
  • Hydrogen-Ion Concentration
  • Ion Channels / physiology*
  • Kinetics
  • Mutation*
  • Saxitoxin / metabolism
  • Sodium / metabolism*


  • Ion Channels
  • Saxitoxin
  • Sodium