Self-associating IgG rheumatoid factors stimulate monocytes to release prostaglandins and mononuclear cell factor that stimulates collagenase and prostaglandin production by synovial cells

Rheumatol Int. 1983;3(4):183-6. doi: 10.1007/BF00541598.


Self-associating IgG rheumatoid factors isolated from three patients with rheumatoid arthritis activated human monocytes to release prostaglandin E2 as well as a previously described mononuclear cell factor, which stimulates human synovial cells to release additional prostaglandin E2 and collagenase. Thus, the immune complexes composed of self-associating IgG rheumatoid factors can contribute to the processes that destroy cartilage and bone in patients with rheumatoid arthritis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Humans
  • Immunoglobulin G / pharmacology*
  • Microbial Collagenase / biosynthesis*
  • Monocytes / metabolism*
  • Monokines
  • Prostaglandins E / biosynthesis
  • Prostaglandins E / metabolism*
  • Proteins / metabolism*
  • Rheumatoid Factor / pharmacology*
  • Synovial Membrane / cytology
  • Synovial Membrane / metabolism*


  • Immunoglobulin G
  • Monokines
  • Prostaglandins E
  • Proteins
  • Rheumatoid Factor
  • Microbial Collagenase