Interferons in the treatment of human cancer

J Clin Oncol. 1984 Apr;2(4):336-52. doi: 10.1200/JCO.1984.2.4.336.

Abstract

The interferons are the best known of biologic antineoplastic agents. Progress with the clinical application of interferons to cancer has been slow and complicated by the need for attention to a new spectrum of therapeutic and toxic effects manifest by the interferons. This summary of current phase I and II trial results with the interferons establishes their clinical potential. The maximally tolerated dosages of the most common species of interferon alpha produced in eukaryotic cells as well as by recombinant DNA technology in bacteria are now described in a variety of different disease states. "Naturally" produced eukaryotic as well as bacterially synthesized interferons have a similar, wide range of biologic effects in vitro and in vivo. Antiviral, antiproliferative, immunologic, and enzymologic functions of the interferons relevant to antineoplastic functions are under study. Knowledge of these mechanisms should improve the clinical results obtained in human cancer. Species and subspecies differences in the activity of interferons may lead to selective use of the pure interferon subspecies, alone or in combination. The use of the interferons and other antineoplastic biologics, such as antibody or chemotherapy, are subsequent goals that are now on the horizon.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adenocarcinoma / therapy
  • Breast Neoplasms / therapy
  • Carcinoma, Bronchogenic / therapy
  • Carcinoma, Squamous Cell / therapy
  • Colonic Neoplasms / therapy
  • Drug Evaluation
  • Female
  • Glioblastoma / therapy
  • Head and Neck Neoplasms / therapy
  • Humans
  • Immunity, Cellular
  • Interferon Type I / adverse effects
  • Interferon Type I / immunology
  • Interferon Type I / therapeutic use*
  • Kidney Neoplasms / therapy
  • Killer Cells, Natural / immunology
  • Laryngeal Neoplasms / therapy
  • Leukemia / therapy
  • Leukemia, Hairy Cell / therapy
  • Lung Neoplasms / therapy
  • Lymphoma / therapy
  • Male
  • Melanoma / therapy
  • Multiple Myeloma / therapy
  • Neoplasms / immunology
  • Neoplasms / therapy*
  • Osteosarcoma / therapy
  • Ovarian Neoplasms / therapy
  • Papilloma / therapy
  • Rectal Neoplasms / therapy
  • Sarcoma, Kaposi / therapy
  • Urinary Bladder Neoplasms / therapy
  • Uterine Cervical Neoplasms / therapy

Substances

  • Interferon Type I