Transferrin binding by peripheral blood mononuclear cells in human lymphomas, myelomas and leukemias

Vox Sang. 1984;46(4):217-23. doi: 10.1111/j.1423-0410.1984.tb00078.x.

Abstract

Significantly more peripheral blood mononuclear cells (PBM) from 39 patients with lymphoma (p less than 0.001), myeloma (p less than 0.001), or leukemia (p less than 0.001-0.025) bind transferrin (Trf) than those of 23 normals. That Trf was bound to a receptor on these cells was shown by the inhibition of these cells bound to 125I-Trf with unlabeled Trf. The paucity of Trf receptors on PBM from normals and their presence on diseased cells prompt a suggestion that Trf receptors may offer a useful approach to the diagnosis and possible treatment of some blood dyscrasias.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cell Transformation, Neoplastic / metabolism
  • Humans
  • Leukemia / immunology*
  • Leukemia, Myeloid, Acute / immunology
  • Lymphocytes / metabolism*
  • Lymphoma / immunology*
  • Multiple Myeloma / immunology*
  • Receptors, Cell Surface*
  • Receptors, Transferrin
  • Transferrin / metabolism

Substances

  • Receptors, Cell Surface
  • Receptors, Transferrin
  • Transferrin