Rearrangements of the transposable mating-type cassettes of fission yeast

EMBO J. 1984 Mar;3(3):603-10.

Abstract

The fission yeast, Schizosaccharomyces pombe, switches mating type every few cell divisions. Switching is controlled by the genes of the mating-type locus, which consists of three components, mat1, mat2-P and mat3-M, each separated by approximately 15 kb. Copy transposition of P (Plus) or M (Minus) information from mat2-P or mat3-M into the expression locus mat1 mediates cell type switching. The mating-type locus undergoes events at high frequency (10(-2)-10(-6)) which stabilize one or other mating type. These events are shown to be rearrangements which result in either deletion or insertion of DNA between cassettes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Ascomycota / genetics*
  • DNA Transposable Elements*
  • DNA, Fungal / genetics
  • Gene Expression Regulation
  • Genetic Linkage
  • Recombination, Genetic
  • Reproduction
  • Schizosaccharomyces / genetics*

Substances

  • DNA Transposable Elements
  • DNA, Fungal