Effect of pectin and cellulose on formation and regression of gallstones in hamsters

Experientia. 1984 Apr 15;40(4):350-1. doi: 10.1007/BF01952545.

Abstract

Male Syrian hamsters were fed a lithogenic diet containing 7% cellulose or 4.2% pectin. After 50 days, pectin was 76% and cellulose 64% less lithogenic than the control diet. Hamsters fed the control diet for 50 days were maintained on that diet for another 50 days or fed diets containing cellulose or pectin. There was a 52% increase in gallstone incidence in hamsters continued on the control diet and a 9% increase in those on cellulose. Pectin promoted regression of gallstones (by 52%).

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cellulose / administration & dosage
  • Cellulose / therapeutic use*
  • Cholelithiasis / diet therapy*
  • Cholelithiasis / prevention & control
  • Cholesterol / metabolism
  • Cricetinae
  • Dietary Fiber / therapeutic use*
  • Liver / metabolism
  • Male
  • Mesocricetus
  • Pectins / administration & dosage
  • Pectins / therapeutic use*

Substances

  • Dietary Fiber
  • Pectins
  • Cellulose
  • Cholesterol