Analysis of sodium current fluctuations in the cut-open squid giant axon

J Gen Physiol. 1984 Feb;83(2):133-42. doi: 10.1085/jgp.83.2.133.


Patch pipettes were used to record the current arising from small populations of sodium channels in voltage-clamped cut-open squid axons. The current fluctuations associated with the time-variant sodium conductance were analyzed with nonstationary statistical techniques in order to obtain an estimate for the conductance of a single sodium channel. The results presented support the notion that the open sodium channel in the squid axon has only one value of conductance, 3.5 pS.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Axons / metabolism*
  • Decapodiformes / metabolism*
  • Electrophysiology
  • Ion Channels / metabolism*
  • Rats
  • Sodium / metabolism*


  • Ion Channels
  • Sodium