Peripheral neuropathy in osteosclerotic myeloma: clinical and electrodiagnostic improvement with chemotherapy

Muscle Nerve. 1984 Feb;7(2):137-41. doi: 10.1002/mus.880070209.


A patient with a severe remote-effect polyneuropathy and other paraneoplastic features of osteosclerotic myeloma improved dramatically with melphalan and prednisone treatment. Serial electrodiagnostic studies provided an objective means of following the response to therapy and documented the improvement. We believe this represents the first reported patient with multifocal osteosclerotic myeloma and a myelomatous polyneuropathy responding to melphalan and prednisone.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Drug Therapy, Combination
  • Electrodiagnosis
  • Female
  • Humans
  • Melphalan / therapeutic use*
  • Multiple Myeloma / complications
  • Multiple Myeloma / diagnosis
  • Multiple Myeloma / drug therapy*
  • Osteosclerosis / complications
  • Osteosclerosis / diagnosis
  • Osteosclerosis / drug therapy*
  • Peripheral Nervous System Diseases / complications
  • Peripheral Nervous System Diseases / diagnosis
  • Peripheral Nervous System Diseases / drug therapy*
  • Prednisone / therapeutic use*


  • Melphalan
  • Prednisone