Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule

Nature. 1984 May 3-9;309(5963):30-3. doi: 10.1038/309030a0.

Abstract

The ability of fibronectin to bind cells can be accounted for by the tetrapeptide L-arginyl-glycyl-L-aspartyl-L-serine, a sequence which is part of the cell attachment domain of fibronectin and present in at least five other proteins. This tetrapeptide may constitute a cellular recognition determinant common to several proteins.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cell Line
  • Fibronectins / metabolism*
  • Kidney
  • Kinetics
  • Oligopeptides / metabolism*
  • Oligopeptides / pharmacology
  • Protein Conformation
  • Rats
  • Receptors, Cell Surface / drug effects
  • Receptors, Cell Surface / metabolism*
  • Receptors, Fibronectin

Substances

  • Fibronectins
  • Oligopeptides
  • Receptors, Cell Surface
  • Receptors, Fibronectin