Oxy-radical toxicity in catecholamine neurons

Neurotoxicology. Spring 1984;5(1):77-82.

Abstract

This article summarizes the evidence that oxy-radicals are involved in the destruction of catecholamine neurons by polyphenolic neurotoxins. Superoxide-mediated damage by 6-hydroxydopamine can be suppressed by intracellular catecholamines, which act as scavengers of the superoxide radical. Administration of exogenous hydroxyl radical-scavenging agents protects peripheral sympathetic neurons from destruction by 6-hydroxydopamine, 6- aminodopamine or 5,7-dihydroxytryptamine. Intraneuronal monoamine oxidase may drive cellular senescence of the nigrostriatal tract in patients with Parkinson's disease by generating hydrogen peroxide and derived oxy-radicals during the metabolism of endogenous dopamine.

MeSH terms

  • Animals
  • Catecholamines / physiology*
  • Dopamine / analogs & derivatives
  • Dopamine / toxicity
  • Free Radicals*
  • Humans
  • Hydroxydopamines / toxicity
  • Hydroxylation
  • Monoamine Oxidase / metabolism
  • Neurons / physiology*
  • Oxidopamine
  • Oxygen / metabolism*
  • Parkinson Disease / metabolism
  • Superoxides / toxicity

Substances

  • Catecholamines
  • Free Radicals
  • Hydroxydopamines
  • Superoxides
  • 6-aminodopamine
  • Oxidopamine
  • Monoamine Oxidase
  • Oxygen
  • Dopamine