The pharmacology of hippocampal theta cells: evidence that the sensory processing correlate is cholinergic

Brain Res. 1984 May 7;299(1):121-31. doi: 10.1016/0006-8993(84)90794-7.

Abstract

The firing repertoires of theta cells in the CA1 and dentate layers of the hippocampal formation of the freely moving rabbit were analyzed during 3 behavioral conditions: (1) voluntary motor patterns, termed type 1 theta behaviors; (2) automatic motor patterns, termed type 2LIA behaviors; (3) alert immobility with presentation of sensory stimuli, termed type 2 theta behavior. Cholinergic manipulations were shown to effect the firing repertoires of theta cells during the type 2 theta behavior condition (sensory processing) and not the other two behavioral conditions. A hypothesis of a sensorimotor processing function of the hippocampal formation is presented and discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Arousal / drug effects
  • Behavior, Animal / drug effects
  • Evoked Potentials / drug effects
  • Hippocampus / drug effects*
  • Motor Activity / drug effects
  • Neurons / drug effects
  • Parasympathomimetics / pharmacology*
  • Rabbits
  • Receptors, Cholinergic / drug effects*
  • Sensation / drug effects*
  • Synaptic Transmission / drug effects*
  • Theta Rhythm

Substances

  • Parasympathomimetics
  • Receptors, Cholinergic