Murine T lymphomas in which the cellular myc oncogene has been activated by retroviral insertion

Cell. 1984 May;37(1):113-22. doi: 10.1016/0092-8674(84)90306-4.


The myc oncogene is implicated here in T lymphocyte neoplasia. Cloning revealed a retroviral insert 0.7-1.3 kb 5' to c-myc in two T lymphomas induced by Soule murine leukemia virus and in a spontaneous T lymphoma ( Tikaut ) of an AKR mouse, a strain in which leukemogenesis involves recombinant retroviruses (MCF viruses). The tumor c-myc mRNAs appear normal but their level is approximately 5-fold higher than in most T lymphomas lacking c-myc rearrangement. Since each insert would be transcribed away from c-myc, its activation cannot involve the promoter of the long terminal repeat (LTR) but could reflect an enhancer, like that demonstrated within the Soule LTR. The Tikaut provirus has an MCF-like recombinant env gene and LTR sequence. MCF-like inserts were found near c-myc in seven of 31 other AKR T lymphomas; two lie 3' to c-myc and the five upstream are oriented away from c-myc. We conclude that a quarter of retrovirus-induced T lymphomas involve activation of c-myc, probably via the LTR enhancer.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Base Sequence
  • DNA Restriction Enzymes
  • DNA Transposable Elements
  • Genes, Viral*
  • Leukemia Virus, Murine / genetics*
  • Leukemia, Experimental / microbiology*
  • Lymphoma / microbiology*
  • Mice
  • Mice, Inbred AKR
  • Nucleic Acid Hybridization
  • Oncogenes*
  • Repetitive Sequences, Nucleic Acid
  • Retroviridae / genetics*
  • T-Lymphocytes / physiology


  • DNA Transposable Elements
  • DNA Restriction Enzymes

Associated data

  • GENBANK/K02594
  • GENBANK/K02595
  • GENBANK/K02731
  • GENBANK/K02732
  • GENBANK/K02733