Murine leukemia virus-induced T-cell lymphomagenesis: integration of proviruses in a distinct chromosomal region

Cell. 1984 May;37(1):141-50. doi: 10.1016/0092-8674(84)90309-x.


A number of mink cell focus-forming (MCF) proviruses was molecularly cloned from mouse lymphoma DNA. From each clone, flanking probes were prepared to detect common integration regions in other MuLV-induced lymphomas. One clone frequently revealed variations in the molecular structure of the corresponding region (Pim-1) in other lymphomas. The results show the following. Changes in the Pim region are seen in 24 out of 93 lymphomas tested. Over 50% of the early T-cell lymphomas show integration in the Pim-1 region. The alterations are seen in different mouse strains and with various MuLVs. The observed variations are caused by the integration of predominantly MCF genomes. All integrations occur in a region spanning less than 20 kb and are associated with the transcriptional activation of a distinct region within the Pim-1 domain. The activated region does not show any homology with 13 known and three putative oncogenes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • Chromosomes / physiology*
  • Cloning, Molecular*
  • DNA Restriction Enzymes
  • DNA, Neoplasm / genetics*
  • DNA, Neoplasm / isolation & purification
  • DNA, Viral / genetics*
  • Genes, Viral
  • Leukemia Virus, Murine / genetics*
  • Leukemia, Experimental / microbiology*
  • Mice
  • RNA, Neoplasm / genetics
  • T-Lymphocytes / physiology*


  • DNA, Neoplasm
  • DNA, Viral
  • RNA, Neoplasm
  • DNA Restriction Enzymes