Slowly digested carbohydrate food improves impaired carbohydrate tolerance in patients with cirrhosis

Clin Sci (Lond). 1984 Jun;66(6):649-57. doi: 10.1042/cs0660649.

Abstract

To test whether impaired carbohydrate tolerance in cirrhosis could be modified by dietary means ten cirrhotic patients, five of them taking insulin, took as breakfast either lentils or wholemeal bread and cottage cheese containing the same amount of carbohydrate and protein. Lentils resulted in significantly diminished blood glucose, insulin (in those not on insulin) and gastric inhibitory peptide responses. Enteroglucagon and neutrotensin levels were high with lentils, suggesting that absorption of lentil carbohydrate continued into the ileum with perhaps some malabsorption, so confirming the results of earlier studies in vitro. However, breath hydrogen studies on a separate group of eight healthy volunteers indicated that the difference in carbohydrate malabsorption between lentil, and wholemeal bread was insignificant. It is suggested that slowly digested carbohydrate foods, such as leguminous seeds, may minimize carbohydrate intolerance in patients with cirrhosis.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blood Glucose / metabolism
  • Diabetes Complications
  • Diabetes Mellitus / metabolism
  • Diet, Diabetic*
  • Dietary Carbohydrates / metabolism*
  • Dietary Fiber / administration & dosage*
  • Female
  • Gastrointestinal Hormones / blood
  • Humans
  • Hydrogen / metabolism
  • Insulin / blood
  • Liver Cirrhosis, Alcoholic / complications
  • Liver Cirrhosis, Alcoholic / diet therapy*
  • Liver Cirrhosis, Alcoholic / metabolism
  • Male
  • Middle Aged

Substances

  • Blood Glucose
  • Dietary Carbohydrates
  • Dietary Fiber
  • Gastrointestinal Hormones
  • Insulin
  • Hydrogen