Antimitotics induce cardiolipin cluster formation. Possible role in mitochondrial enzyme inactivation

Biochim Biophys Acta. 1984 Jun 15;799(2):199-202. doi: 10.1016/0304-4165(84)90296-4.

Abstract

We demonstrate here that drugs which inactivate cytochrome c oxidase are able to segregate cardiolipin essential for the enzyme activity, in a separate phase inaccessible for the enzyme. A molecular explanation of the drug-induced aggregation process is proposed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acridine Orange / pharmacology*
  • Animals
  • Calorimetry, Differential Scanning
  • Cardiolipins / metabolism*
  • Cattle
  • Doxorubicin / pharmacology*
  • Electron Transport Complex IV / antagonists & inhibitors*
  • Ethidium / pharmacology*
  • Liposomes
  • Macromolecular Substances
  • Mitochondria, Heart / enzymology*
  • Pulmonary Surfactants

Substances

  • Cardiolipins
  • Liposomes
  • Macromolecular Substances
  • Pulmonary Surfactants
  • Doxorubicin
  • Electron Transport Complex IV
  • Ethidium
  • Acridine Orange