Abstract
We demonstrate here that drugs which inactivate cytochrome c oxidase are able to segregate cardiolipin essential for the enzyme activity, in a separate phase inaccessible for the enzyme. A molecular explanation of the drug-induced aggregation process is proposed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acridine Orange / pharmacology*
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Animals
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Calorimetry, Differential Scanning
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Cardiolipins / metabolism*
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Cattle
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Doxorubicin / pharmacology*
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Electron Transport Complex IV / antagonists & inhibitors*
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Ethidium / pharmacology*
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Liposomes
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Macromolecular Substances
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Mitochondria, Heart / enzymology*
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Pulmonary Surfactants
Substances
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Cardiolipins
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Liposomes
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Macromolecular Substances
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Pulmonary Surfactants
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Doxorubicin
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Electron Transport Complex IV
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Ethidium
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Acridine Orange