Cannabinoids in glaucoma II: the effect of different cannabinoids on intraocular pressure of the rabbit

Curr Eye Res. 1984 Jun;3(6):841-50. doi: 10.3109/02713688409000797.


Thirty-two different cannabinoids were tested for their ability to reduce intraocular pressure (IOP) in the rabbit. These included many of delta 9- and delta 8-THC derivatives and metabolites along with other natural and synthetic cannabinoids. In addition, some non-cannabinoid constituents of Cannabis were screened using the same model. All compounds were administered intravenously, while only a few were tested topically in mineral oil. Water soluble derivatives of delta 9- and delta 8-THC were prepared and tested topically in aqueous solution. The data revealed that certain derivatives of delta 9-and delta 8-THC were more active in lowering IOP than the parent cannabinoids. In addition, compounds other than delta 9- and delta 8-THC and their derivatives were shown to have activity.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Administration, Topical
  • Animals
  • Cannabinoids / pharmacology
  • Cannabinoids / therapeutic use*
  • Dronabinol / pharmacology
  • Glaucoma / drug therapy*
  • Intraocular Pressure / drug effects*
  • Rabbits
  • Structure-Activity Relationship


  • Cannabinoids
  • delta-8-tetrahydrocannabinol
  • Dronabinol
  • cannabichromene