Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
, 1 (8), 945-51

Distantly Related Sequences in the Alpha- And Beta-Subunits of ATP Synthase, Myosin, Kinases and Other ATP-requiring Enzymes and a Common Nucleotide Binding Fold

Comparative Study

Distantly Related Sequences in the Alpha- And Beta-Subunits of ATP Synthase, Myosin, Kinases and Other ATP-requiring Enzymes and a Common Nucleotide Binding Fold

J E Walker et al. EMBO J.

Abstract

The alpha- and beta-subunits of membrane-bound ATP synthase complex bind ATP and ADP: beta contributes to catalytic sites, and alpha may be involved in regulation of ATP synthase activity. The sequences of beta-subunits are highly conserved in Escherichia coli and bovine mitochondria. Also alpha and beta are weakly homologous to each other throughout most of their amino acid sequences, suggesting that they have common functions in catalysis. Related sequences in both alpha and beta and in other enzymes that bind ATP or ADP in catalysis, notably myosin, phosphofructokinase, and adenylate kinase, help to identify regions contributing to an adenine nucleotide binding fold in both ATP synthase subunits.

Similar articles

See all similar articles

Cited by 1,604 PubMed Central articles

See all "Cited by" articles

References

    1. Arch Biochem Biophys. 1975 Mar;167(1):311-21 - PubMed
    1. J Biol Chem. 1972 Oct 25;247(20):6624-30 - PubMed
    1. Annu Rev Biochem. 1979;48:103-31 - PubMed
    1. Annu Rev Biochem. 1981;50:681-714 - PubMed
    1. Eur J Biochem. 1975 May;54(1):117-26 - PubMed

Publication types

MeSH terms

LinkOut - more resources

Feedback