Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequences

Nature. 1984;309(5971):757-62. doi: 10.1038/309757a0.

Abstract

Two related, but distinct, cDNA clones have been isolated and sequenced from a functional murine cytotoxic T-lymphocyte clone. The genes corresponding to these cDNA are expressed and rearranged specifically in T cells and both have similarities to immunoglobulin variable and constant region genes. It is concluded that these genes code for the two subunits of the heterodimeric antigen receptor on the surface of the T cell; its complete deduced primary structure is presented.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cloning, Molecular*
  • DNA / analysis*
  • DNA Restriction Enzymes
  • Genes*
  • Humans
  • Immunoglobulin Constant Regions / genetics
  • Immunoglobulin Variable Region / genetics
  • Macromolecular Substances
  • Receptors, Antigen, T-Cell / genetics*

Substances

  • Immunoglobulin Constant Regions
  • Immunoglobulin Variable Region
  • Macromolecular Substances
  • Receptors, Antigen, T-Cell
  • DNA
  • DNA Restriction Enzymes

Associated data

  • GENBANK/X00696
  • GENBANK/X00697