Sequence of a Drosophila segmentation gene: protein structure homology with DNA-binding proteins

Nature. 1984 Jul 5-11;310(5972):25-31. doi: 10.1038/310025a0.


Mutations in the fushi tarazu (ftz) locus of Drosophila result in embryos with half the usual number of body segments. The sequences of the wild-type gene, a temperature-sensitive allele and a dominant mutant allele are presented. A portion of the conserved protein domain present in ftz and several homoeotic genes resembles the DNA-binding region of prokaryotic DNA-binding proteins, and is also similar to products of the yeast mating-type locus.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alleles
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cloning, Molecular
  • DNA / analysis
  • DNA Restriction Enzymes
  • DNA-Binding Proteins / genetics*
  • Drosophila melanogaster / embryology
  • Drosophila melanogaster / genetics*
  • Genes*
  • Mutation
  • Nucleic Acid Conformation


  • DNA-Binding Proteins
  • DNA
  • DNA Restriction Enzymes

Associated data

  • GENBANK/K01951
  • GENBANK/K03136
  • GENBANK/X00854