Fructose-1,6-biphosphatase activity in the intestinal mucosa of developing rats

Am J Physiol. 1984 Jun;246(6 Pt 1):G683-6. doi: 10.1152/ajpgi.1984.246.6.G683.


Fructose-biphosphatase (EC activity was determined in the proximal and distal parts of the small intestinal mucosa of rats 1-30 days of age. Activity was found to increase to a maximum on about the 10th postnatal day and then to decrease. It was always higher in the proximal than in the distal portion of the gut. The enzyme showed a wide range of pH optimum around 7.0 and was inhibited by AMP. In 10-day-old rats activity determined 24 or 48 h after a single injection of cortisone or triiodothyronine was significantly decreased. This effect was no longer found for cortisone in 14-day-old animals. Weaning 18-day-old rats to a high-fat diet for 5 or 7 days delayed but did not prevent the usual decrease in activity seen at weaning.

MeSH terms

  • Animal Population Groups / metabolism*
  • Animals
  • Animals, Suckling / metabolism*
  • Cortisone / pharmacology
  • Dietary Fats / pharmacology
  • Female
  • Fructose-Bisphosphatase / metabolism*
  • Intestinal Mucosa / enzymology*
  • Male
  • Rats / growth & development
  • Rats / metabolism*
  • Rats, Inbred Strains
  • Tissue Distribution
  • Triiodothyronine / pharmacology


  • Dietary Fats
  • Triiodothyronine
  • Fructose-Bisphosphatase
  • Cortisone